Endocrine Abstracts

Background: Thyroid dysfunction and lipid profile are associated with cardiovascular disease in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the association between thyroid function, lipid concentrations, C-reactive protein (CRP) and homocysteine in patients with AIT.Patients and methods: We assessed thyroid function tests, BMI, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides (TG), apoli...

Aims: To examine whether treated autoimmune thyroiditis (AIT) and Graves’ disease (GD) are associated with increased cardiovascular risk factors.Patients and methods: We analysed the levels of total cholesterol (TC), HDL, LDL, triglycerides (TG), ApoB, ApoA1, Lp[a], homocysteine, CRP, folic acid and vitamin B12 in 50 patients with GD and in 130 patients with AIT, after normalization of thyroid function. Patients with GD were treated with propylthiou...

Objective: The aim of this study was to examine the hypothesis that thyroid function, in euthyroid subjects with autoimmune thyroiditis (AIT), is associated with insulin resistance, serum lipid concentrations, and other cardiovascular (CV) risk factors. Subjects and Methods: We recorded thyroid function tests, BMI, insulin resistance markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR), the Quantitative Insulin Sensitivity Check Index (QUICKI), ...

Introduction: Obesity is a heterogenous disorder. One of its subtypes that has been recently described is termed the metabolically healthy, but obese (MHO) individuals. Preliminary evidence suggests that this could be due to lower visceral fat levels and earlier onset of obesity.Objectives: To determine the prevalence of MHO in a sample of obese patients. To evaluate whether body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are...

Introduction: Several studies have suggested an association of thyrotropin (TSH) and free thyroxine (FT4) levels within the reference range with morbidity and mortality in the general population. Low free triiodothyronine (FT3) has also been associated with a poor prognosis in several conditions. However, the association between FT3 levels within the reference range and the risk of mortality in the general population remains uncertain.Methods: We evaluat...

Introduction: Thyroid hormones modulate the insulin sensitivity and glucose metabolism. The interrelation between thyroid autoimmunity, thyroid function, glucose metabolism and cardiovascular risk factors remains uncertain.Methods: We recorded thyroid function tests, BMI, IR markers comprising the Homeostasis Model Assessment for insulin resistance (HOMA-IR and HOMA-B), the Quantitative Insulin Sensitivity Check Index (QUICKI), HISI (Hepatic Insulin Sens...

IntroductionNon-classical congenital adrenal hyperplasia (NC-CAH) is a chronic disease characterized by excessive androgen production. Affected children may have their quality of life negatively affected by the awareness of a medical condition, symptoms of hyperandrogenism and the burden of daily medication administration. Pediatric Quality of Life Inventory 4.0 (PedsQL) is a validated tool to assess health-related QoL (HRQoL).Meth...

Introduction: Non-alcoholic fatty liver disease (NAFLD) and Heart Failure with Preserved Ejection Fraction (HFpEF) are two syndromes with increasing clinical relevance, mainly due to the rising prevalence of metabolic syndrome. Despite sharing a common metabolic background, the association between NAFLD severity and HFpEF has not yet been well explored.Aim: To evaluate the association of NAFLD steatosis and fibrosis scores with cardiovascular function an...

Introduction: Diabetic foot infection imposes a significant burden and is a major cause of non-traumatic limb amputation. Antibiotic therapy plays a crucial role in the management these patients. In our institution, empirical antibiotic therapy is tailored to the presence of risk factors for multidrug-resistant microorganisms. For patients without risk factors, empirical intravenous amoxicillin-clavulanate at a dose 2.2 g every 8h is used. For patients with risk factors such a...

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...